Metabolic influence of walnut phenolic extract on mitochondria in a colon cancer stem cell model
Walnut phenolic extract (WPE) reduces proliferation and enhances differentiation of colon cancer stem cells (CSCs). The present study investigated the metabolic influence of WPE on the mitochondrial function of colon CSCs to determine its underlying mechanism.
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Traditional Chinese medicine Astragalus polysaccharide enhanced antitumor effects of the angiogenesis inhibitor apatinib in pancreatic cancer cells on proliferation, invasiveness, and apoptosis
Background: Traditional chemotherapy and molecular targeted therapy have shown modest effects on the survival of patients with pancreatic cancer. The current study aimed to investigate the antitumor effects of apatinib, Astragalus polysaccharide (APS), and the combination of both the drugs in pancreatic cancer cells and further explore the molecular mechanisms in vitro.
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Universal screening not recommended for high-risk groups
In finalizing its draft recommendations for prostate cancer screening in men ages 55 to 69, the U.S. Preventive Services Task Force (USPSTF) has put itself broadly in alignment with guidelines from other organizations.
The USPSTF now recommends that for this age group, the decision to be screened for prostate cancer with prostate-specific antigen (PSA)-based testing should be an individual one, reported USPSTF Vice Chair Alex H. Krist, MD, MPH, of the Virginia Commonwealth University in Richmond, and colleagues in JAMA.
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Eleven experts convened by the National Toxicology Program (NTP) over a three day period to review the draft technical reports from the NTP’s cell phone radiation studies concluded that there is “clear evidence” that exposure to cell phone radiation caused a rare cancer in the hearts of male rats, and “there is equivocal evidence” in the hearts of female rats.
The expert panel also reported “some evidence” that cell phone radiation exposure caused brain cancer in male and female rats and cancer of the adrenal glands in male rats.
Additionally, “equivocal evidence” of cancer risk was reported in the pituitary, adrenal, and prostate glands and pancreas and liver in male rats and adrenal glands in female rats.
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High Doses Of Vitamin C To Improve Cancer Treatment Passes Human Safety Trial
Clinical trials found that it is safe to regularly infuse brain and lung cancer patients with 800 — 1000 times the daily recommended amount of vitamin C as a potential strategy to improve outcomes of standard cancer treatments. In a work presented March 30, 2017 in Cancer Cell, University of Iowa researchers also show pathways by which altered iron metabolism in cancer cells, and not normal cells, lead to increased sensitivity to cancer cell death caused by high dose vitamin C.
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Cancer treatments are often hard on patients, but the side effects and challenges are necessary to control or even destroy tumor cells.
Now researchers say there may be a way to make those treatments work even better. In a study published in Cancer Cell, scientists say that giving people high doses of vitamin C during treatment may weaken cancer cells and make them more vulnerable to the effects of chemotherapy and radiation.
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